The interaction and mediation role of intrinsic capacity in the association between asthma and all-cause mortality.

ABSTRACT: Asthma and intrinsic capacity (IC) decline were individually examined with mortality, yet the complex interplay between them remains largely unknown. This study aimed to examine the potential roles of IC decline in the association between asthma and all-cause mortality. We conducted a prospective cohort study using data from UK Biobank, where IC decline was defined as a decline in any domain of psychological, sensory, vitality, and locomotion. Cox proportional hazard models were used to examine the associations between asthma, IC decline, and all-cause mortality. The relative excess risk due to additive interaction (RERI) was calculated. Mediation analysis was performed to explore the mediating effect of IC decline. And a four-way decomposition method was utilized to quantify both the inte

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC12644723 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature