Glucose shields RINm5F beta cells against arsenic-induced apoptosis.

ABSTRACT: Type 2 Diabetes (T2D) is characterized by hyperglycemia due to pancreatic beta cell failure and the development of insulin resistance. Although high carbohydrate intake and arsenic exposure increase the risk of developing T2D, their interactions and mechanisms associated with changes in insulin signaling pathways that lead to beta-cell apoptosis remain unknown. We determined the effects of in vitro exposure for 48 and 72 h to arsenic (As, 2 µM), glucose (Gluc, 22 mM), and their interaction (As + Gluc) on the apoptosis in RINm5F insulinoma beta-cells and explored the possible mechanisms dependent on alterations in insulin signaling pathways. We found that arsenic induced early apoptosis, while glucose co-treatment reduced arsenic-induced apoptosis. Mechanistically, co-treatment with As + Gl

SUBMITTER: Ortiz-Huidobro RI 

PROVIDER: S-EPMC12644731 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature