Effect on three-dimensional collective cell organization of minimal curvature surfaces.

ABSTRACT: Collective cell organization can be influenced by surface curvature, as studied in cylindrical, spherical, and sinusoidal surfaces; however, hyperbolic geometries have been overlooked due to their biofabrication complexity, despite their presence in biological structures, and their potential role in minimizing cell bending energy. Therefore, understanding cell behavior in complex-hyperbolic geometries is important to design in vitro biomimetic platforms and scaffolds. This work studies the role of curvature on collective cell spatiotemporal growth and adhesion, using the gyroid, a minimal periodic hyperbolic surface. The gyroid biofabrication has been limited by its interconnected curved structure, which is solved here by using its fundamental unit of symmetry, parametrized in terms of mea

SUBMITTER: Flores-Jimenez MS 

PROVIDER: S-EPMC12644750 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature