Distinct responses to non-autonomous UPR^ER mediated by glutamatergic and octopaminergic neurons.

ABSTRACT: The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR^ER) is one such conserved mechanism, which is critical for the maintenance of several major functions of the ER during stress, including protein folding and lipid metabolism. Hyperactivation of the UPR^ER by overexpression of the major transcription factor, xbp-1s, solely in neurons drives lifespan extension as neurons send a neurotransmitter-based signal to other tissues to activate UPR^ER in a non-autonomous fashion. Previous work identified serotonergic, dopaminergic, and tyraminergic neurons in this signaling paradigm. To further expand our understandi

SUBMITTER: Coakley AJ 

PROVIDER: S-EPMC12644781 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature