Permethrin induces epileptic susceptibility via activation of Na⁺ channels and rise in glutamate.

ABSTRACT: Permethrin, a common pyrethroid insecticide, is extensively used to control insect pests and has been widely detected in the environment. A growing body of epidemiological studies has revealed a substantial increase in the prevalence of epilepsy among individuals highly exposed to pesticides. However, the mechanism of action of permethrin in epilepsy remains elusive. In this study, we investigate the effects of permethrin on zebrafish and mice exposed to environmentally relevant concentrations. Acute exposure to permethrin induces dose-dependent epileptiform symptoms in zebrafish, including whirlpool-like movement, clonus-like convulsions, nystagmus and neuronal hyperactivity. Extended exposure results in neuronal hyperexcitation, impaired neurogenesis and enhanced glial cell hyperplasia i

SUBMITTER: Su M 

PROVIDER: S-EPMC12644824 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature