Lactate metabolism-related differentially expressed genes reveal biological mechanisms underlying sarcopenia.

ABSTRACT: Sarcopenia (SARC), a progressive degenerative disorder associated with aging, is characterized by a gradual loss of muscle mass and strength and imposes major burdens on individuals and society. Current diagnostic and therapeutic methods for SARC remain limited, highlighting the urgent need for novel biomarkers. The present research was designed to investigate the role of lactate metabolism-related differentially expressed genes (LMRDEGs) in SARC, identify key genes and pathways, and develop a diagnostic model for the disease. Differentially expressed genes (DEGs) were identified using data from the Gene Expression Omnibus database. Gene set enrichment analysis was used to determine signaling pathways associated with the DEGs. Pearson's correlation analysis was used to quantify the strengt

SUBMITTER: Li Y 

PROVIDER: S-EPMC12644826 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature