A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand.

ABSTRACT: Candida auris, one of the emerging multidrug-resistant Candida species, was first discovered in 2009 from the ear canal of a patient in Tokyo, Japan. Since then, several studies exhibit the possible threats of C. auris due to its versatile resistance to frontline antifungal agents. The number of studies focusing on genetic variants associated with multidrug resistance has risen over a decade. In this study, we retrieved eight C. auris strains, originated from clinical isolates in Bangkok, Thailand, and sequenced all genomes using long-read oxford nanopore technology. We have identified genome-wide single nucleotide polymorphisms (SNPs) and found that the typical genetic variation, Y132F, in ERG11 was shared between fluconazole-resistant strains, as previously reported. The fluconazole-resi

SUBMITTER: Opassathian K 

PROVIDER: S-EPMC12644842 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature