Investigating inflammation of adipose tissue in a diet induced obesity model of OA in female sprague dawley rats.

ABSTRACT: This study was aimed at evaluating the disturbance of mesenteric fat, and the infrapatellar fat pad (IFP) of the knee, and their potential contribution to systemic inflammation and local inflammation in the knee, and the development of knee joint OA in female Sprague-Dawley rats.Female rats were randomized into two groups; a Chow-fed group (Chow) and rats fed a high-fat and high-sucrose diet (HFS). Body composition, serum lipid profile, insulin resistance, serum and synovial fluid inflammatory markers, knee joint degeneration, and adipocyte size in the two fat depots were assessed after 12 weeks of the diet interventions. Mesenteric fat macrophage infiltration and infrapatellar fat pad fibrosis were also quantified.Rats from the HFS group had higher body fat, serum triglycerides levels, se

SUBMITTER: Abughazaleh N 

PROVIDER: S-EPMC12644849 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature