Effective therapeutic strategies against Pseudomonas aeruginosa and Burkholderia Cepacia complex infections.

ABSTRACT: Pseudomonas aeruginosa and Burkholderia cepacia complex (Bcc) can cause serious nosocomial infections. The reported misidentification of Bcc as P. aeruginosa, besides the contrasting susceptibility patterns between these two pathogens, underscores the importance of accurate identification and the need to explore therapeutic approaches that could eradicate them both. Our study aimed to evaluate the susceptibilities of both pathogens to different antibiotics and test the effectiveness of different antimicrobial combinations. In addition, we compared conventional phenotypic and automated identification methods using the VITEK 2 system with PCR amplification and sequencing of recA gene to differentiate between P. aeruginosa and Bcc. Amplification by PCR of the recA gene showed high specificity

SUBMITTER: Helmy NAM 

PROVIDER: S-EPMC12644862 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature