Mannitol versus furosemide for prevention of cisplatin-induced nephrotoxicity in a multicenter retrospective cohort study.

ABSTRACT: Cisplatin (cis-diamminedichloroplatinum [CDDP]) is a widely used anticancer drug with a significant risk of nephrotoxicity. This study aimed to compare the nephroprotective effects of mannitol and furosemide as forced diuretics in patients receiving CDDP-based chemotherapy. This multicenter retrospective study analyzed 472 patients with cancer receiving CDDP (≥ 60 mg/m²) with either mannitol or furosemide as forced diuretics. Patient characteristics were balanced using inverse probability treatment weighting. Nephrotoxicity was assessed using the Common Terminology Criteria for Adverse Events (ver. 5.0) criteria. The results showed that the incidence of nephrotoxicity was significantly lower in the furosemide group than in the mannitol group (6.2% vs. 23.2%, p < 0.007). The mean

SUBMITTER: Harimitsu Y 

PROVIDER: S-EPMC12644863 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature