Cannabinoids shift the basal ganglia microRNA m⁶A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaques.

ABSTRACT: Epitranscriptomic modifications [N6-methyladenosine (m⁶A)] regulate various diseases, including cancer and inflammation. Despite their functional relevance in neural development and differentiation, the role of m⁶A modifications in HIV neuropathogenesis is unknown. Using anti-N6-methyladenosine (m⁶A) antibody-immunoprecipitation and microarray profiling, we identified m⁶A modifications in miRNAs in basal ganglia (BG) of uninfected (VEH) and SIV-infected Rhesus macaques (RMs) on combination anti-retroviral therapy (ART) and either VEH-treated (VEH/SIV/ART) or THC:CBD-treated (THC:CBD/SIV/ART). HIV/SIV infection promoted an overall hypomethylated miRNA m⁶A profile. While THC:CBD did not significantly impact the overall hypomethylated m

SUBMITTER: Okeoma CM 

PROVIDER: S-EPMC12644866 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature