PER3 suppresses lung adenocarcinomatous cell proliferation/migration through activating AMPK/mTOR pathway.

ABSTRACT: Dysregulation of circadian rhythm genes is related to the increased risk of development of various human cancers. This study investigated the biological roles of Period circadian regulator 3 (PER3) in the development and progression of lung adenocarcinoma and related underlying mechanisms. The expression of PER3 was decreased in lung adenocarcinoma and its low expression was correlated with advanced disease stages. Lentiviral-transduced overexpression of PER3 inhibited but PER3 silencing promoted proliferation, migration and invasion of lung adenocarcinomatous cells, suggesting that it played an anti-carcinogenic role in the development and progression of lung adenocarcinoma. Mechanistically, PER3 overexpression elevated the phosphorylation level of AMPK and reduced the phosphorylation lev

SUBMITTER: Yuan G 

PROVIDER: S-EPMC12644904 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature