OLR1 is closely related to poor prognosis and immune cell infiltration in gastric cancer.

ABSTRACT: Oxidized low-density lipoprotein receptor 1 (OLR1) in gastric cancer (GC) progression and immune cell infiltration remains unclear. This study aimed to investigate the impact of OLR1 on GC progression and to elucidate its association with immune cell infiltration in GC. OLR1 expression profiles in GC and paired normal tissues were analyzed using datasets from the TCGA, GTEx, and GEO databases, with validation conducted through quantitative real-time PCR (qPCR) and immunohistochemistry (IHC). Differentially expressed genes (DEGs) associated with OLR1 were identified through gene set enrichment analysis (GSEA) and functional enrichment analysis. We evaluated the role of OLR1 in GC immune cell infiltration. In addition, Cox regression and Kaplan-Meier analyses were conducted on OLR1 for its p

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12644914 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature