Hemodynamic characteristics and drug deposition in cerebral aneurysm sac.

ABSTRACT: Patient-specific cerebral aneurysms exhibit complex hemodynamics insights that influence thrombus formation, wall remodeling, and therapeutic delivery. The article presents a high-fidelity, multi-parametric CFD analysis of nine distinct aneurysm cases using 3-D model-resolved meshes, non-Newtonian Casson rheology, and steady-state flow conditions. Further, the Lagrangian particle tracking was employed to assess drug transport and hemodynamic metrics such as WSS and normalized residence time (NRT) were evaluated, along with vortex dynamics, indicators including helicity (H) and Q criterion to characterize rotational flow structures. Results reveal that narrowed neck models (m₁, m₂, m₅, m₈) exhibit weak vortex structures and dominant axial washout

SUBMITTER: Singh D 

PROVIDER: S-EPMC12644918 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature