Catalpol-a compound from <i>Rehmannia glutinosa</i> can improve hyperlipidemia by modulating gut microbiota and endogenous metabolic pathways.

ABSTRACT:

Introduction

Catalpol, an iridoid glycoside derived from Rehmannia glutinosa, is widely recognized for its ability to reduce blood glucose levels. However, its potential therapeutic effects on hyperlipidemia (HL) have yet to be investigated.

Methods

To identify novel lipid-lowering effects of catalpol potentially exerted through the modulation of the gut microbiota and endogenous metabolic pathways, Sprague-Dawley (SD) rats were provided a high-fat diet (HFD) to induce an HL state. The lipid-lowering efficacy of catalpol was assessed using biochemical test kits. Subsequently, 16S rRNA gene sequencing was employed to analyze alterations in gut microbial composition in HL rats before and after catalpol treatment. Ultra-high-performance liquid chromatography coupled with

SUBMITTER: Pei X 

PROVIDER: S-EPMC12644921 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature