Multimodal analysis of whole slide images in colorectal cancer.

ABSTRACT: Multimodal models have enabled the integration of digital pathology, radiology, clinical information, and omics data to enhance Colorectal cancer (CRC) care. This systematic review critically appraises Multimodal digital pathology techniques applied in CRC, their performance, and contrasts them with foundation models. We identified and screened 1601 studies published between January 2014 and August 2024 using PubMed, Web of Science, Scopus, and IEEE Xplore (PROSPERO protocol: 635831). The quality and bias of the 22 eligible studies were assessed using the Newcastle-Ottawa Scale. Our findings suggest that majority of the studies integrated different modalities to enhance diagnostic accuracy and survival prediction. Various fusion techniques have been used to extract novel features. Most stu

SUBMITTER: Jonnagaddala J 

PROVIDER: S-EPMC12644990 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature