Identification of inducible HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency.

ABSTRACT: HIV persists in diverse tissues, with distinct cellular reservoirs presenting a major barrier to a cure and requiring targeted therapeutic strategies to address this heterogeneity. Here, we develop tissue models of HIV latency using human tonsillar, intestinal and cervicovaginal tissues. These models reveal differential HIV infection across CD4⁺ T-cell subpopulations, with ART partially restoring CD4⁺ T cells and reducing intact HIV DNA. T follicular helper cells (T_{FH CD69+ CCR7-}) are the primary inducible reservoir in tonsils, while tissue-resident memory cells (T_{RM CD69+ CD49a+}) dominate in the intestine. Identification of markers for inducible reservoirs shows that CD69, CD45RO, and PD-1 are shared across tissues, while CXCR5 in tonsils and CD

SUBMITTER: Gallego-Cortes A 

PROVIDER: S-EPMC12645015 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature