Inflammation and oxidative stress are associated with major adverse cardiovascular events in adults with preclinical hypertension.

ABSTRACT: Inflammation and oxidative stress increase with rising blood pressure. Adults with preclinical hypertension (systolic 120-129 mmHg) have a heightened risk of major adverse cardiovascular events (MACE). However, it remains unclear whether inflammation and oxidative stress contribute to MACE risk in this population. We conducted an observational study involving 5405 adults in the Framingham Offspring and Generation III cohorts. Exclusion criteria were anti-hypertensive therapy, history of cardiovascular disease, estimated glomerular filtration rate below 60 ml/min/1.73 m², and type-2 diabetes. Blood pressure categories were defined using the American Heart Association blood pressure criteria as normal, elevated (preclinical hypertension), stage 1, and stage 2. MACE was a composite

SUBMITTER: Gimblet CJ 

PROVIDER: S-EPMC12645037 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature