Microwave-Enhanced Synthesis of 2-Styrylquinoline-4-Carboxamides With Promising Anti-Lymphoma Activity.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, characterized by significant clinical and molecular heterogeneity. Here, we report the design and synthesis of a novel series of 2-styrylquinoline-4-carboxamides via an efficient microwave-assisted organic synthesis (MAOS) approach. This strategy enabled the rapid and high-yielding isolation of derivatives 4a-z and 4aa-ah in three steps from commercially available isatin. Among the 34 compounds synthesized, 24 showed antiproliferative activity in vitro, with compound 4i displaying sub-micromolar IC₅₀ values across multiple lymphoma cell lines, including SU-DHL-8 and TOLEDO. Mechanism of action studies demonstrated that 4i was able to induce G₂/M cell-cycle arrest and DNA synthesis suppression, coupled

SUBMITTER: Sardo I 

PROVIDER: S-EPMC12645083 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature