Phenolic Glycoside Monomer from <i>Reed Rhizome</i> Inhibits Melanin Production <i>via</i> PI3K-Akt and Ras-Raf-MEK-ERK Pathways.

ABSTRACT:

Introduction

Melanogenesis, the process responsible for melanin production, is a critical determinant of skin pigmentation. Dysregulation of this process can lead to hyperpigmentation disorders.

Methods

In this study, we identified a novel Reed Rhizome extract, (1'S, 2'S)-syringyl glycerol 3'-O-β-D-glucopyranoside (compound 5), and evaluated its anti-melanogenic potential in zebrafish models and in vitro assays. Compound 5 inhibited melanin synthesis by 36.66% ± 14.00% and tyrosinase in vivo by 48.26% ± 6.94%, surpassing the inhibitory effects of arbutin. Network pharmacological analysis revealed key targets, including HSP90AA1, HRAS, and PIK3R1, potentially involved in the anti-melanogenic effects of compound 5.

Results

Molecular docking studies supported the

SUBMITTER: Pang M 

PROVIDER: S-EPMC12645109 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature