Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program.

ABSTRACT: Hypoglycemia is a preventable adverse treatment effect in diabetes patients, but genetic markers to identify those with increased susceptibility are lacking. We performed a case/control genome-wide association study (GWAS) of hypoglycemia in U.S. Million Veteran Program (MVP) participants with medication-treated diabetes. Case participants had an outpatient random serum/plasma glucose <70 mg/dL or an emergency department visit for hypoglycemia. GWAS was stratified by race/ethnicity, adjusted for age at MVP enrollment, sex, and top 10 population-specific principal components, followed by multipopulation meta-analysis. Secondary analyses examined genetic associations with hypoglycemia stratified by diabetes medication exposure as well as replication in UK Biobank and the Action to Control Ca

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC12645173 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature