Riboflavin-sensitized photoinduced degradation of donepezil hydrochloride: kinetic and computational insights for pharmaceutical formulation.

ABSTRACT: Donepezil (DPZ) photosensitized degradation by riboflavin (RF) at pH 2.0-12.0 has been carried out in aerobic and anaerobic conditions under UV and visible irradiation to give an idea to pharmaceutical formulators to develop a stable co-formulation to administer to elderly patients with neurodegenerative diseases (Alzheimer's disease, Parkinson's disease). The photolysis rate constants (k _obs) in aerobic and anaerobic conditions in the presence of RF (0.1-0.5 × 10^-4 M) range from 0.25-11.5 and 0.025-1.120 × 10^-2 min^-1, respectively. RF catalyzes the photodegradation of DPZ, and the second-order (k ₂) constants in aerobic and anaerobic conditions range from 0.32 to 8.22 and 0.032 to 0.805 × 10^-2 M^-1 m

SUBMITTER: Khan T 

PROVIDER: S-EPMC12645192 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature