Opportunities for early oral therapy for prosthetic hip and knee joint infections (PJI): clinical experience at a large health authority.

ABSTRACT:

Objectives

We described the clinical outcomes and estimated cost savings from switching patients to early oral therapy from intravenous (IV) therapy for prosthetic joint infections (PJI) based on predefined criteria.

Methods

Retrospective observational study in a large health authority consisting of 12 acute care hospitals in Canada. Patient demographics, microbiological and treatment data were collected for all patients with first episode of knee or hip PJI in 2022. Treatment failure rates, allergic or adverse reactions to IV or oral treatment, and hospital readmission rates were reported for those who met criteria for early switch to oral therapy.

Results

Fifty-one patients were included. Thirty-seven patients (73%) had knee PJI, with debridement, antibiotics, and i

SUBMITTER: Wong M 

PROVIDER: S-EPMC12645242 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature