Genetics of Common Obesity in Children and Adolescents.

ABSTRACT: Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component. Polygenic obesity is the most frequent, having an important interaction with environmental factors. A scoping review was conducted to identify existing literature on the association between common genetic variation and obesity-related traits in children and adolescents. We retrieved 180 studies that were classified as genome-wide studies, meta-analyses targeting selected variants, and original studies with a targeted genotype approach. Most genome-wide meta-analyses have been conducted in Caucasian populations and have co

SUBMITTER: Leon-Reyes G 

PROVIDER: S-EPMC12645270 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature