Prescription drug monitoring programs and perioperative opioid prescribing and adverse events.

ABSTRACT:

Introduction

Most states mandate clinicians to review prescription drug monitoring program (PDMP) databases before prescribing opioids, but the association with perioperative outcomes is unknown.

Methods

We analyzed 2016-2019 Medicare claims for patients ≥65 undergoing surgery in 21 states that enacted PDMP use mandates in 2017-2018 vs states without mandates during 2016-2019. Procedure-level, difference-in-differences models adjusted for patient demographics, prior opioid use, mental health, prior substance use disorders, comorbidities, surgeon specialty, and procedure type. Outcomes included discharge opioid prescriptions, days supplied, total and daily morphine milligram equivalents, high-risk prescribing (≥7-day supply or opioid-benzodiazepine overlap), and 30-day post-d

SUBMITTER: Constantin J 

PROVIDER: S-EPMC12645282 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature