Bisphenol A Impairs Spatial Memory by Inhibiting Hippocampal Excitatory Neuronal Response During Learning Events.

ABSTRACT: Bisphenol A (BPA) exposure can impair learning and memory in rodents, but the underlying systematic neural mechanism remains unclear. Due to the important role of the hippocampus for learning and memory, in this study, we systematically investigated the neural circuit, neuron structure, and function of the hippocampus after BPA exposure. First, by employing a virus tracing technique, we observed a decrease in the neural projection ratio of excitatory neural neurons from the "Entorhinal Cortex-Dentate Gyrus-CA3-CA1" and "Entorhinal Cortex-CA1" circuits. Furthermore, BPA exposure led to impairments of the branching complexity and electrophysiological properties of hippocampal neurons. Additionally, fiber photometry experiments revealed that BPA exposure reduces the level of real-time activit

SUBMITTER: Bi N 

PROVIDER: S-EPMC12645298 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature