Heat Exposure Changes Lung Function, Biomarkers of Airway Injury, and Airway Microbiota: A Randomized, Crossover Trial.

ABSTRACT: High temperature exposure has been identified as a significant risk factor for respiratory diseases. However, causal evidence is needed to confirm the respiratory effects associated with heat exposure and to elucidate the underlying mechanisms. We conducted a randomized crossover trial among healthy adults in Shanghai, China. Participants received 2 h exposures to moderate-temperature (22 °C) and high-temperature (32 °C) conditions. Spirometry tests, fractional exhaled nitric oxide (FeNO) measurements, and collections of pharyngeal secretion and peripheral blood samples were performed before and after each session. Pharyngeal microbiota was analyzed via 16S rRNA amplicon sequencing. Serum biomarkers, including Clara cell protein (CC16) and Chitinase-3-like protein 1 (YKL-40) were also meas

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12645300 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature