Enantioselective Modulation of Inflammatory Response through MAPK Pathway by Wavelike Chiral Nanoparticles.

ABSTRACT: Infectious inflammation remains a major global health issue, so novel strategies to alleviate inflammatory responses are urgently required. Cinnabar (α-HgS) used in traditional Chinese medicine shows protective effects against inflammation, but low anti-inflammatory efficacies ascribed to poor solubility and bioavailability have hindered extensive applications of cinnabar. Nanoscale chirality provides chances to improve efficacies through enantiomer-dependent interactions between cells and chiral cinnabar nanoparticles (HgSNPs). Herein HgSNPs with intrinsically wavelike chirality were prepared through a one-pot seedless method, exhibiting efficacious alleviation of inflammation in vitro and in vivo by HgSNPs with laevorotatory chirality (l-HgSNPs) rather than those with dextr

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12645301 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature