Condition-Specific Growth Charts for Children With Alagille Syndrome.

ABSTRACT:

Importance

Different degrees of growth delay have been reported in children with Alagille syndrome (ALGS), yet these patients are routinely evaluated using standard growth charts.

Objective

To develop condition-specific growth charts for ALGS using modern statistical approaches.

Design, setting, and participants

This case series used data from the international, multicenter Global Alagille Alliance (GALA) study accrued between May 14, 2018, and March 20, 2023. Children born at full term between January 1, 1997, and August 31, 2019, with a clinically and/or genetically confirmed ALGS diagnosis and their native liver were included. Data from children with a known history of prematurity were excluded for the development of the growth charts. Data were analyzed from March

SUBMITTER: Huysentruyt K 

PROVIDER: S-EPMC12645329 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature