Physiologic Transition During Delayed Cord Clamping With Assisted Ventilation in Preterm Infants: A Secondary Analysis of the VentFirst Trial.

ABSTRACT:

Importance

Assisted ventilation during delayed cord clamping (DCC) may improve the physiologic transition of extremely preterm infants immediately after birth.

Objective

To determine whether assisted ventilation during 120 seconds of DCC was associated with reduced higher-level resuscitative interventions (intubation, chest compressions, or epinephrine administration) compared with DCC for 30 to 60 seconds followed by resuscitation.

Design, setting, and participants

This was a secondary analysis of the VentFirst randomized clinical trial that was conducted from September 2, 2016, through February 21, 2023, at 12 centers in the US and Canada. Infants born at 23 weeks 0 days' to 28 weeks 6 days' gestational age (GA) were included.

Intervention

Infants randomized

SUBMITTER: Fang JL 

PROVIDER: S-EPMC12645335 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature