Gestational Weight Gain and Pregnancy Outcomes After GLP-1 Receptor Agonist Discontinuation.

ABSTRACT:

Importance

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are contraindicated in pregnancy. Discontinuation of GLP-1RAs proximal to pregnancy could affect gestational weight gain and pregnancy outcomes.

Objective

To compare gestational weight gain and pregnancy outcomes with and without exposure to GLP-1RAs before or during early pregnancy.

Design, setting, and participants

Retrospective cohort study of 149 790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025, within a single academic health system.

Exposure

A GLP-1RA order between 3 years before and 90 days after conception, with propensity score matching of each exposed pregnancy to 3 unexposed pregnancies.

Main outcomes and measures

The primary outcome was gestational wei

SUBMITTER: Maya J 

PROVIDER: S-EPMC12645404 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature