Using Mendelian randomization to investigate etiologic heterogeneity across renal cell carcinoma subtypes.

ABSTRACT:

Background

Renal cell carcinoma (RCC) histological subtypes clear cell RCC (ccRCC; >75% of cases) and papillary RCC (papRCC; ∼15%) exhibit distinct molecular and genetic profiles, patient demographics, and prognoses. Previous epidemiologic studies have identified several risk factors for overall RCC, although few have explored differences in etiology across subtypes.

Methods

For this study, we applied two-sample Mendelian randomization (MR) to findings from a genome-wide association study of RCC (27 213 cases, 488 019 controls) to investigate the effects of RCC risk factors with ccRCC (15 507 cases) and papRCC (2103 cases). We also conducted case-only MR analyses contrasting ccRCC and papRCC cases to test for heterogeneity in risk factor effects across subtypes.

Results</

SUBMITTER: Winter TD 

PROVIDER: S-EPMC12645421 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature