Exploring the antimicrobial properties of synthetic tetrahydro-2<i>H</i>-1,3,5-thiadiazine-2-thiones (THTTs) through <i>in vitro</i> and <i>in silico</i> antileishmanial and antibacterial studies.

ABSTRACT: Infectious diseases represent a significant health concern due to their high rates of morbidity and mortality. Despite significant advances in the understanding of the pathogenic infection, existing therapies to control those infections are still unsatisfactory. Herein, a total of 18 alkyl/aryl/aralkylamines or amino acids attached 1,3,5-thiadiazine-2-thiones (4a-i, 5a-g, 6 and 7) were synthesized via one pot domino synthesis and assessed their in vitro leishmanicidal and bactericidal potential. Their structures were confirmed through advanced spectroscopic techniques (¹H-NMR, ¹³C-NMR, and HRMS analysis). The compounds inhibited promastigotes of Leishmania tropica with IC₅₀ values ranging from 1.50 µg mL^-1 to 72.04 µg mL

SUBMITTER: Khan R 

PROVIDER: S-EPMC12645442 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature