Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation.

ABSTRACT: The retrosplenial cortex (RSC) is a critical brain region that is activated during spatial memory tasks and plays a crucial role in the consolidation of long-term memory. Various classes of RSC excitatory neurons across different laminar layers serve as the central hub for neuronal connections between the RSC and other brain regions, such as the hippocampus. Despite the established role of the RSC in spatial memory, the transcriptomic signature of the neuronal subtypes in the RSC during spatial memory consolidation remained elusive. Here, we used unbiased and targeted spatial transcriptomics to identify the RSC transcriptional signature after a spatial memory task. Genes related to transcription regulation, protein folding, and mitogen-activated protein kinase pathways were upregulated in

SUBMITTER: Bliese SR 

PROVIDER: S-EPMC12645481 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature