³¹P-MRS-Measured Phosphocreatine Recovery Kinetics in Human Muscles in Health and Disease-A Systematic Review and Meta-Analysis.

ABSTRACT: The noninvasive, in vivo measurement of postexercise phosphocreatine (PCr) recovery kinetics using 31-phosphorus magnetic resonance spectroscopy (³¹P-MRS) is a highly prevalent method for assessing skeletal muscle energetics. However, ³¹P-MRS methodology is notoriously laboratory-specific, leading to uncertainty about the normal range of PCr recovery kinetics among healthy individuals, as well as relationships with disease and demographic factors. This systematic review and meta-analysis characterized the normal range of PCr recovery kinetics from ³¹P-MRS in human skeletal muscles across the lifespan, differences between healthy and those with muscle-related diseases, and relationships between intermuscular PCr recovery measurements and demographic factors.

SUBMITTER: Singh M 

PROVIDER: S-EPMC12645491 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature