Association of Inpatient Prescribing of First-Generation Antihistamines With Delirium in Older Adults: A Cross-Sectional Study.

ABSTRACT:

Background

Small studies have reported associations between first-generation antihistamines and delirium. It is unclear whether first-generation antihistamines cause clinically important delirium among older adult inpatients.

Objective

To estimate the association between inpatient physician prescribing of first-generation antihistamines and delirium among older general medicine inpatients.

Methods

Cross-sectional study using the GEMINI database of inpatient admissions between April 1, 2015, and March 31, 2022, across 17 hospitals in Ontario, Canada, among people aged 65 years and older. The main exposure was the proportion of attending physicians' admissions by quartile that included a first-generation antihistamine prescription. The primary outcome was inpatient deli

SUBMITTER: Bridgman AC 

PROVIDER: S-EPMC12645522 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature