Angiotensin-converting enzyme 2 regulates the placental response to repeated hypoxia-reoxygenation insult.

ABSTRACT: Fetal growth restriction is linked to placental oxidative stress owing to defective placentation and hypoxia-reoxygenation (H/R). Angiotensin-converting enzyme 2 (ACE2), a key regulator of oxidative stress, is reduced in placentae of fetuses with growth restriction. We aimed to develop a physiologically relevant model of repeated H/R to determine the protective role of ACE2 during repeated H/R insult. Human term placental explants (n = 8 per group) were cultured for 24 h in normoxia (8% O₂), non-physiological H/R [6 h cycles of 1% (hypoxia chamber) and 8% O₂ (incubator)] or our novel physiological H/R model (6 h cycles of 1% and 8% O₂ in a single hypoxia chamber), with or without recombinant human (rh)ACE2. Physiological H/R, in contrast to non-physiologica

SUBMITTER: Brooker IA 

PROVIDER: S-EPMC12645529 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature