SCORE2-Older Persons (SCORE2-OP): Validation and Added Value of Excessive Daytime Sleepiness in a French Cohort.

ABSTRACT:

Background

Cardiovascular diseases are the leading cause of death worldwide, particularly in older adults. While the Systematic Coronary Risk Evaluation 2-Older Persons (SCORE2-OP) model estimates 10-year cardiovascular risk in this population, its validation in general European cohorts remains limited. Given growing relationships between sleep disturbances and cardiovascular risk, we aimed to validate SCORE2-OP in a French cohort and assess the incremental value of excessive daytime sleepiness (EDS).

Methods

We included 4626 participants aged 70+ from the Three-City cohort, without cardiovascular disease and dementia at baseline. The SCORE2-OP model calibrated for low-cardiovascular risk regions was used to estimate 10-year cardiovascular risk. Calibration was assessed usin

SUBMITTER: Andriambelosoa T 

PROVIDER: S-EPMC12645540 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature