Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation.

ABSTRACT: N-Methyl-d-aspartate receptors (NMDARs) are known for their role in mediating a calcium-permeable, slow component of excitatory synaptic transmission. These receptors play important roles in multiple facets of brain functions, and their dysfunction has been implicated in neurological disease aetiology. Here, we describe the actions of a positive allosteric modulator (PAM), EU1622-240, on NMDARs within the hippocampal circuit. EU1622-240 is a pan-PAM that enhances the function of all GluN2 subunit-containing NMDARs with submicromolar potency, with the strongest effects on GluN2C- and GluN2D-containing NMDARs. Previously, we have shown that EU1622-240 enhances the maximal response, prolongs the response time course, enhances agonist potency and reduces single channel conductance. Using whole

SUBMITTER: Xing H 

PROVIDER: S-EPMC12645542 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature