Reduced osmoresponsiveness in magnocellular neuroendocrine neurones during chronic salt-loading.

ABSTRACT: Here, we studied the effects of salt-loading in rats on the electrophysiological behaviour of neurones that secrete oxytocin and vasopressin. After 7 days of salt-loading, the basal firing rate of both vasopressin cells and oxytocin cells in urethane-anaesthetized rats was increased by less than 1 spike s^-1, which is much less than expected from the hyperosmolality induced by saltloading. The neuronal responsiveness to acute osmotic stimuli was also markedly impaired, with no change in their responses to non-osmotic stimuli. We then undertook a systematic search of the literature for studies in salt-loaded rats that had measured oxytocin or vasopressin secretion, plasma osmolality, haematocrit or pituitary hormone content, and reviewed them in light of our electrophysiological f

SUBMITTER: Lozic M 

PROVIDER: S-EPMC12645551 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature