Cobalt-Catalyzed Four-Component Carbonylative Synthesis of γ-Thioesters and γ-Thioamides from Thioethers and Ethylene.

ABSTRACT: Multicomponent carbonylative reactions have proven to be indispensable for constructing heterocycles and highly functionalized molecular frameworks and represent an attractive strategy for alkene functionalization. Herein, we report a cobalt-catalyzed four-component carbonylation of thioethers and ethylene gas with diverse nucleophiles, affording a series of γ-thioether amides and γ-thioether esters. The reaction features a broad substrate scope, good chemo- and regioselectivity, and excellent functional-group tolerance.

SUBMITTER: Mao X 

PROVIDER: S-EPMC12645581 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature