Prospective association of the triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio with anxiety risk in a community-based cohort: a UK Biobank study.

ABSTRACT:

Objective

To investigate whether the triglyceride-glucose (TyG) index and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, as clinical surrogates of insulin resistance, predict the risk of anxiety, and to examine the potential mediating role of plasma proteins.

Design

Prospective cohort study.

Setting

Community-based population cohort in the United Kingdom.

Participants

A total of 412 767 participants aged 40-69 years without anxiety at baseline and with available data on TyG index and TG/HDL-C ratio were included. Among them, 43 991 participants had proteomic data with 2923 unique plasma proteins measured.

Primary and secondary outcome measures

The primary outcome was the incidence of first-episode anxiety. The main exposures w

SUBMITTER: Ren H 

PROVIDER: S-EPMC12645597 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature