Mortality related to procedural sedation and analgesia: a 10-year review of a nationwide medical adverse events database.

ABSTRACT: Procedural sedation and analgesia (PSA) is generally considered safe, yet fatal events remain poorly characterised across procedures and specialties. We retrospectively reviewed the Japan Council for Quality Health Care nationwide adverse-event database (2012-2021), searching narrative reports with 40 Japanese keywords for sedation terms and drug names. Only reports in which PSA was deemed the primary cause of death were included; non-procedural sedation, planned general anaesthesia and procedure-induced injuries were excluded. Among 10 011 reports identified via keyword search, 805 described deaths and 23 were attributed to PSA. Fatalities clustered in gastroenterology (73.9%), particularly endoscopic retrograde cholangiopancreatography (ERCP; 34.8%). Most cases were high-risk patients ag

SUBMITTER: Takase H 

PROVIDER: S-EPMC12645623 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature