Neutrophil-to-lymphocyte ratio predicts mortality for sepsis-induced coagulopathy: a retrospective study.

ABSTRACT:

Background

Sepsis often leads to coagulation dysfunction, potentially progressing to disseminated intravascular coagulation (DIC), leading to higher mortality. Sepsis-induced coagulopathy (SIC), an early stage of DIC, benefits from early detection and intervention. Neutrophil-to-lymphocyte ratio (NLR) predicts mortality in inflammatory diseases, but its link to SIC mortality is unclear. This study explored NLR's relevance to clinical outcomes in SIC patients.

Methods

SIC patients from the MIMIC-IV database were divided into four groups by NLR quartiles. The primary outcome was 28-day mortality, while secondary outcomes included 90-day and 1-year mortality, intensive care unit (ICU) and hospital mortality. The association between NLR and clinical outcomes in SIC patients was

SUBMITTER: Zhong H 

PROVIDER: S-EPMC12645672 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature