Urinary metabolome at birth in patients with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and long-term neurodevelopmental outcomes: a 7-year follow up.

ABSTRACT:

Background

Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal mortality and morbidity, yet no validated biomarkers currently exist to predict long-term outcomes. We investigated the potential of the neonatal urinary metabolomic profile as a predictor of long-term neurodevelopmental outcomes in HIE newborns treated with therapeutic hypothermia (TH).

Methods

We conducted a longitudinal study in neonates with HIE undergoing TH. Urine samples collected during TH were analyzed using untargeted metabolomics via mass spectrometry. Based on long-term follow-up outcomes, patients were categorized into two groups: the adverse outcome (AO) group, defined by perinatal death, cerebral palsy, and/or an intelligence quotient (IQ) < 70, and the favourable outcome (FO) grou

SUBMITTER: Ancona C 

PROVIDER: S-EPMC12645678 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature