Efficacy and safety of probiotic supplements on cognitive function: a systematic review and meta-analysis of randomized clinical trials.

ABSTRACT:

Objective

This systematic review and meta-analysis aimed to evaluate the efficacy and safety of probiotic supplementation on cognitive function in individuals over 18 years of age.

Methods

Randomized clinical trials (RCTs) assessing the impact of probiotics on cognitive function were included. Searches were conducted across four medical databases from inception to August 2024. The outcomes were cognitive function measured by Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Cognition Categorical Fluency Test (CFT), and adverse events. Data were extracted and analyzed using a random-effects model, with results reported as mean differences (MD) and relative risks (RR) with 95% confidence intervals (CI). To evaluate statistical heterogeneity, the I² st

SUBMITTER: Calzada-Gonzales N 

PROVIDER: S-EPMC12645680 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature