Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages.

ABSTRACT:

Background

The rising prevalence of artemisinin-resistant malaria parasites in Africa underscores the urgent demand for new and effective therapeutic options. Historically, natural products have demonstrated significant anti-Plasmodium efficacy, indicating their potential as a source for malaria drug discovery. Extracts and fractions from Terminalia ivorensis and Terminalia brownii previously exhibited promising anti-Plasmodium potency; however, a thorough assessment of their pharmacodynamics across all asexual blood stages of Plasmodium falciparum and elucidation of their mode of action remains to be conducted. Products from the active fractions of T. ivorensis (Ti^WEa) and T. brownii (Tb^MMeOH:Ea) were investigated throughout the asexual-blood and sexual stage

SUBMITTER: Tali MBT 

PROVIDER: S-EPMC12645700 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature