Transcription factor FOXC2 regulates miR-145/ADAMTS5 axis to inhibit angiogenesis in hepatocellular carcinoma via circular RNA 0002898.

ABSTRACT:

Background

Circular RNAs (circRNAs), a novel class of single-stranded, covalently closed non-coding RNA molecules, have been increasingly recognized for their roles in the cellular landscape over the past decade. These molecules are predominantly localized within the cytoplasm of eukaryotic cells and have been implicated in the pathogenesis of a spectrum of cancers. Despite this, the specific contributions of circRNAs to hepatocellular carcinoma (HCC) have yet to be fully delineated.

Methods

Our research has identified that cyclic RNA0002898 is downregulated in HCC, with its reduced expression correlating with advanced tumor grade and diminished patient survival outcomes. Furthermore, we have demonstrated that the transcription factor forkhead box C2 (FOXC2) regulates the ex

SUBMITTER: Yuan J 

PROVIDER: S-EPMC12645709 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature