Immunosuppressed patients with COVID-19 pneumonia in ICU: clinical characteristics and factors influencing outcomes.

ABSTRACT:

Introduction

COVID-19 severely impacted global health, especially older adults and those with comorbidities. Immunosuppressed patients are at high risk for severe outcomes, yet studies yield conflicting mortality rates for this group. This study examines the clinical characteristics and outcomes of immunosuppressed (IS) versus non-immunosuppressed (nIS) patients with COVID-19 in ICUs.

Methods

A multicenter, observational case-control study included 5,824 ICU patients with COVID-19 from the CIBERESUCICOVID study. Patients were categorized as IS or nIS based on history of transplantation, HIV, active neoplasia, and use of immunosuppressive drugs or corticosteroids. The primary outcome was 90-day mortality; secondary outcomes included in-hospital, 15-day, 30-day and 1-year mort

SUBMITTER: Galli F 

PROVIDER: S-EPMC12645730 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature