Molecular polymorphism of tau aggregates in Pick's disease.

ABSTRACT:

Background

Tau protein is central to progressive neuropathological changes in many neurodegenerative diseases. Although the trajectory by which tau pathology spreads through neural networks has been studied, the molecular processes that drive disease are unknown. Characterizing these processes requires imaging tools that supplement neuropathological examination with information about the molecular organization of lesions while preserving details of their anatomical location. High-resolution cryo-electron microscope studies require isolation of material which destroys information on variation of lesion structure with location. Immunohistochemistry identifies principal constituents of lesions but provides little information about molecular organization. To bridge this knowledge gap,

SUBMITTER: Liu J 

PROVIDER: S-EPMC12645749 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature